San Francisco will be without two of their biggest stars again, but should have their talented passer back in the saddle.

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

The 49ers won't have their best pass rusher when they face the Bills on Sunday. Nick Bosa will miss his second game in a row with an oblique injury ...

Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, ...

The San Francisco 49ers are on the verge of falling out of contention for a playoff spot in the NFC after consecutive losses ...

Head coach Kyle Shanahan shared the final injury report on QB Brock Purdy, DL Nick Bosa and others and discussed the team's ...

First comes Brock Purdy, the team's star quarterback, who missed Week 12 with a right shoulder. While Purdy is still ...

Brock Purdy is expected to return Sunday night against the Bills, but offensive tackle Trent Williams, defensive end Nick ...

San Francisco 49ers quarterback Brock Purdy appears to be making strides in his recovery from a shoulder injury. During the ...

San Francisco 49ers quarterback Brock Purdy is listed as questionable for Sunday's game against the Buffalo Bills, but he ...

Bosa (hip/oblique) has been ruled out for Sunday's game against Buffalo, Lindsey Pallares of the 49ers ' official site reports.

The Niners could be without stars like quarterback Brock Purdy, offensive tackle Trent Williams, and defensive end Nick Bosa.