Running back Christian McCaffrey refuses to buy into the doom and gloom surrounding the San Francisco 49ers since two straight losses sent them below .500.

The San Francisco 49ers announced they have waived wide receiver Ronnie Bell ahead of Sunday's game against the Buffalo Bills. The 49ers Communications

ORCHARD PARK, N.Y. (AP) — Running back Christian McCaffrey refuses to buy into the doom and gloom surrounding the San Francisco 49ers since two straight losses ... This January, the NFL had to push back by one day Buffalo's 31-17 wild-card playoff ...

The San Francisco 49ers have been hit hard by injuries throughout the season. Another player added himself to the list, but he’s continuing to play. All-Pro linebacker Fred Warner revealed that he’s been playing through a fracture ankle for weeks.

Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth Lombardi Trophy. The Niners have mad

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got destroyed by the Green Bay Packers. Granted Brock Purdy didn't play, but the 49ers didn't look like an NFC contender.

San Francisco 49ers linebacker Fred Warner says he has been playing through a fractured bone in his ankle since Week 4. Warner suffered the injury

We thought San Francisco was poised for a massive second-half run after the Week 9 bye with Christian McCaffrey back, but the 49ers haven't looked good over their last three contests.  It wasn't a surprise the 49ers fell to the Green Bay Packers on Sunday with so many key contributors out.

There's no two ways about it: the San Francisco 49ers are having a brutal season. Taking the field in Week 1 with sky-high expectations, what with eight-year head coach Kyle Shanahan having just taken his team to the Super Bowl last year,

The San Francisco 49ers could have Brock Purdy back soon, as the quarterback was recently seen throwing passes in a video after being limited in practice just a few days ago due to injury concerns. Brock Purdy could return to the starting role for the San Francisco 49ers in Week 13 against the Buffalo Bills on the road.

Buffalo Bills head coach Sean McDermott has ruled out tight end Dalton Kincaid for Sunday night's game against the San Francisco 49ers.